Domain-to-domain coupling in voltage-sensing phosphatase
نویسندگان
چکیده
منابع مشابه
Domain-to-domain coupling in voltage-sensing phosphatase
Voltage-sensing phosphatase (VSP) consists of a transmembrane voltage sensor and a cytoplasmic enzyme region. The enzyme region contains the phosphatase and C2 domains, is structurally similar to the tumor suppressor phosphatase PTEN, and catalyzes the dephosphorylation of phosphoinositides. The transmembrane voltage sensor is connected to the phosphatase through a short linker region, and phos...
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The voltage-sensing phosphatase (VSP) is the first example of an enzyme controlled by changes in membrane potential. VSP has four distinct regions: the transmembrane voltage-sensing domain (VSD), the inter-domain linker, the cytosolic catalytic domain, and the C2 domain. The VSD transmits the changes in membrane potential through the inter-domain linker activating the catalytic domain which the...
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The modular architecture of voltage-gated K(+) (Kv) channels suggests that they resulted from the fusion of a voltage-sensing domain (VSD) to a pore module. Here, we show that the VSD of Ciona intestinalis phosphatase (Ci-VSP) fused to the viral channel Kcv creates Kv(Synth1), a functional voltage-gated, outwardly rectifying K(+) channel. Kv(Synth1) displays the summed features of its individua...
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Advances in our understanding of the roles of phosphatidylinositol phosphates in controlling cellular functions such as endocytosis, exocytosis and the actin cytoskeleton have included new insights into the phosphatases that are responsible for the interconversion of these lipids. One of these is an entirely novel class of phosphatase domain found in a number of well characterized proteins. Pro...
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It came to prominence... in 1996 when synaptojanin was cloned and shown to participate with dynamin in synaptic vesicle recycling. Synaptojanin is a phosphatidylinositol 5-phosphatase able to remove the phosphate from the 5-position of phosphatidylinositol(4,5)bisphosphat e (PtdIns(4,5)P2). The Sac domain is a region of homology between the amino terminus of synaptojanin and the otherwise unrel...
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ژورنال
عنوان ژورنال: Biophysics and Physicobiology
سال: 2017
ISSN: 2189-4779
DOI: 10.2142/biophysico.14.0_85